Zn2+ Inhibits Coronavirus RNA Polymerase Activity

'Coronavirus RNA Polymerase Activity' = = replication




Quote:

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture Published: November 4, 2010

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176

[the whole article is just a click away.]


Read it.

If you want to.


.


WWW search.....
RNA Polymerase

"RNA polymerase, is an enzyme that synthesizes RNA from a DNA template."
- wiki


If we can stop the COVID virus     from replicating     IN THE BODY,
then the COVID virus is defeated.   !!!!!

Stopping the COVID virus from replicating, IN THE BODY, really isn't that difficult to do.

But who [and WHO], does not want you to have this knowledge ??? **


**
Right at this moment, it is 1/ BIG PHARMA, and 2/ LEFTIST, WOKE governments around the world.

But why so ?

YOU need to ask yourself, that question !


Control.

Power.


.


"Right is only in question between equals, and while the strong do what they can, the weak suffer what they must."
- Thucydides (460-400 B.C.) Greek Historian


'Right' ?....your human rights and freedoms, which our forefathers secured, for you and for me.

OK couple of things

1. The zinc compound used in vitro, not in vivo. Even the authors considered this and said it needed further testing.

"Clearly, an in-depth analysis of nidovirus RdRps, e.g. through structural analysis and subsequent mutational studies targeting aforementioned cysteines and histidines, is required to provide further insight into and a structural basis for the Zn2+-induced inhibitory effects on RdRp activity documented in this study. Such studies may, however, be complicated when Zn2+ binding proves to be very transient in nature and not detectable with currently available methods."


2. The zinc compound used wasn't as water-soluble as other zinc compounds and thus has a higher selective toxicity which may cause issues in vivo.



Again, cause for future study, but doesn't indicate taking it.

yadda

shush

i have brought this up before

you are insane if you arent taking zinc BUT THERES NO MONEY IN IT FOR BIG PHARMA AND THE GOVERNMENT WANT TO BE THE SAVIOURS BY PROVIDING THE THREAT

the deadly virus

AND THE CURE....THE VACCINE.


they will never ever ever in a million years allow something as simple as zinc to be promoted.  it would be a matter of a good diet and personal responsibility.

far from it.

the big corporations have just declared YOU WILL BE BANNED FROM FACEBOOK IF YOU CALL SOMEONE FAT.

obesity and poor nutrition are the religion of our pandering elites.
they get to sell more crap food and they get to sell more crap medicines to the fat zinc deficient chode  ;D ;D ;D ;D ;D ;D ;D ;D

"Conclusion

Currently, indirect evidence suggests zinc may potentially reduce the risk, duration and severity of SARS-CoV-2 infections, particularly for populations at risk of zinc deficiency including people with chronic disease co-morbidities and older adults. Direct evidence to determine if zinc is effective for either prevention or treatment of SARS-CoV-2 is pending. In the interim, assessing zinc status of people with chronic diseases and older adults, as part of a SARS-CoV-2 clinical work-up, is reasonable as both groups have a higher risk of zinc deficiency/insufficiency and poorer outcomes from SARS-CoV-2."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395818/

lee wrote on Sep 14^th, 2021 at 4:00pm:

"Conclusion Currently, indirect evidence suggests zinc may potentially reduce the risk, duration and severity of SARS-CoV-2 infections, particularly for populations at risk of zinc deficiency including people with chronic disease co-morbidities and older adults. Direct evidence to determine if zinc is effective for either prevention or treatment of SARS-CoV-2 is pending. In the interim, assessing zinc status of people with chronic diseases and older adults, as part of a SARS-CoV-2 clinical work-up, is reasonable as both groups have a higher risk of zinc deficiency/insufficiency and poorer outcomes from SARS-CoV-2." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395818/

pending ;D ;D ;D ;D


do you think big government or big pharma are going to study this  :D :D :D.


17/ Politics, the media, science, and the healthcare industries are all corrupt, to varying degrees. Scientists and doctors can be bought as easily as politicians.

Our freedom in this world started to erode when the twin towers were demolished and they blamed it on some shepherds from the middle east and then to save us from terrorism freedom had to suffer.

Today they have once again seized the opportunity from the covid sickness to further diminish what freedoms were left over from the 9/11 demolitions.

 

aquascoot wrote on Sep 14^th, 2021 at 3:20pm:

yadda shush

Yup.

You are right.

Not many people are willing to try, to know what is [really] going on around them.


Proverbs 25:2
It is the glory of God to conceal a thing: but the honour of kings is to search out a matter.


Psalms 14:2
The LORD looked down from heaven upon the children of men, to see if there were any that did understand, and seek God.


If you do not understand something [due to lack of wisdom],
God's word say's ask God to bestow wisdom upon you !

James 1:5
If any of you lack wisdom, let him ask of God, that giveth to all men liberally, and upbraideth not; and it shall be given him.


Matthew 7:8
For every one that asketh receiveth; and he that seeketh findeth; and to him that knocketh it shall be opened.
9  Or what man is there of you, whom if his son ask bread, will he give him a stone?
10  Or if he ask a fish, will he give him a serpent?
11  If ye then, being evil, know how to give good gifts unto your children, how much more shall your Father which is in heaven give good things to them that ask him?


1 Thessalonians 5:21
Prove all things; hold fast that which is good.
22  Abstain from all appearance of evil.



The Bible, it is a guide to our steps, if we search it.


.




aquascoot wrote on Sep 14^th, 2021 at 3:20pm:

the big corporations have just declared YOU WILL BE BANNED FROM FACEBOOK IF YOU CALL SOMEONE FAT.

[Yadda shakes his head from side to side]

Hmmm.

All the poor snowflakes out there !!      :)

....who just want someone to show them to the garden path.

Ajax wrote on Sep 14^th, 2021 at 4:07pm:

Our freedom in this world started to erode when the twin towers were demolished and they blamed it on some shepherds from the middle east and then to save us from terrorism freedom had to suffer. Today they have once again seized the opportunity from the covid sickness to further diminish what freedoms were left over from the 9/11 demolitions.

the way people were forced to "submit" at airports after 9/11 was revealing.
no one would DARE make a joke at an airport.
the population behave like jews in a concentration camp.
no humor, total authoritarian control and brutal punishment for any non conforming behaviour.

this sort of nonsense at airports (xraying 3 yo's and making a 3 yo take off their shoes, should have stopped after 6 months.

yet 20 years on, the authorities still get a hard on by doing it .

covid is exactly the same

you wouldnt dare crack a joke to the authorities or be anything but submissive or you will be beaten into submission.

it should stop at christmas but it wont.

when you give chodes a bit of power (airport security or public health officers), they will never relinquish it.

zuby understands them well


2/ At least 20% of the population has strong authoritarian tendencies, which will emerge under the right conditions.

7/ Most people believe the government acts in the best interests of the people. Even many who are vocal critics of the government.

12/ Most people value safety and security more than freedom and liberty, even if said 'safety' is merely an illusion.


14/ A significant % of people thoroughly enjoy being subjugated.

lee wrote on Sep 14^th, 2021 at 4:00pm:

"Conclusion Currently, indirect evidence suggests zinc may potentially reduce the risk, duration and severity of SARS-CoV-2 infections, particularly for populations at risk of zinc deficiency including people with chronic disease co-morbidities and older adults. Direct evidence to determine if zinc is effective for either prevention or treatment of SARS-CoV-2 is pending. In the interim, assessing zinc status of people with chronic diseases and older adults, as part of a SARS-CoV-2 clinical work-up, is reasonable as both groups have a higher risk of zinc deficiency/insufficiency and poorer outcomes from SARS-CoV-2." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395818/

Suggest and may. Hardly a ringing endorsement.

John Dillermand wrote on Sep 14^th, 2021 at 5:33pm:

Suggest and may. Hardly a ringing endorsement.

And nothing since 2020.

But where did I endorse it? ;)

lee wrote on Sep 14^th, 2021 at 5:53pm:

John Dillermand wrote on Sep 14th, 2021 at 5:33pm: Suggest and may. Hardly a ringing endorsement. And nothing since 2020. But where did I endorse it? ;)

Did I say that you endorsed it?

Is that you gweggy? ;D ;D ;D ;D

lee wrote on Sep 14^th, 2021 at 5:56pm:

Is that you gweggy? ;D ;D ;D ;D

Not really my point was the conclusion you linked to wasn;'t a ringing endorsement for the use of zinc.

John Dillermand wrote on Sep 14^th, 2021 at 5:59pm:

Not really my point was the conclusion you linked to wasn;'t a ringing endorsement for the use of zinc.

No it wasn't. It was an interim item from medical experts. But zinc is not on a copyright list so big pharma would have no interest in trials.;)

lee wrote on Sep 14^th, 2021 at 6:15pm:

John Dillermand wrote on Sep 14th, 2021 at 5:59pm: Not really my point was the conclusion you linked to wasn;'t a ringing endorsement for the use of zinc. No it wasn't. It was an interim item from medical experts. But zinc is not on a copyright list so big pharma would have no interest in trials.;)

Or that the interim items aren't exactly setting the world on fire in terms of results.

Find a recent study -

"4. Zinc: effects on COVID-19 patients

In a recently concluded Conference on Coronavirus Disease of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Dr. Güerri-Fernández and colleagues presented the retrospective analysis data on the impact of zinc on the mortality of COVID-19 patients among the hospital admitted patients in Spain. Out of 249 studied patients, there was 8% (21 patients) mortality. The investigators found a significantly lower plasma level of zinc in COVID-19 patients who died (43 μg/dl) than the patients who survived (63.1 μg/dl). After adjusting different variables, the investigators showed each unit increase of plasma zinc at the time of hospital admission resulted in a 7% reduced risk of in-hospital mortality. Also, less than 50 μg/dl of a plasma zinc level at the hospital admission was associated with a 2.3-fold increased risk of in-hospital deaths as compared to the patients with a plasma zinc level of 50 μg/dl or higher, suggesting the importance of maintaining adequate zinc balance [21]. In a similar line of study, serum zinc level was found to be relatively low in samples collected from COVID-19 patients compared to the healthy counterparts. The average serum zinc level was remarkably low in the samples collected from the non-surviving COVID-19 patients (n = 6) as compared to the surviving COVID-19 patients (n = 29) [94]. In another uncontrolled case series study with COVID-19 patients, a high dose of oral zinc salt resulted in clinical recovery, improved oxygenation, and less shortness of breath among those patients [95]. A study conducted in Japan on 62 patients with COVID-19 showed a close association between low serum zinc level and severity of the disease [5]. The investigators also found serum zinc level as a predictive factor for a critical illness of patients with COVID-19 [5]. In a different study, the fasting zinc level in blood in patients with COVID-19 (n = 47) was significantly lower than the healthy controls (n = 45)."

"5. Conclusion

The holistic approach of maintaining an adequate nutritional balance with healthy eating habits and keeping an active lifestyle are likely to reduce the disease burden of the COVID-19 pandemic [103], [104], [105], [106], [107], [108], [109], [110]. Without the mass availability of effective vaccines or specific drugs to treat or control COVID-19 infection, social distancing and home isolation are the most recommended measures employed to minimize the spread of COVID-19-associated infection. However, consuming zinc has the potential to provide an additional shield against the illness [111], [112], [113], [114], possibly by reducing viral load and enhancing the immunity of the COVID-19 patients (Fig. 2). The elevated intracellular concentration of zinc could inactivate the RNA-dependent RNA polymerase, the core viral replication enzyme [19], which could reduce viral replication and might have the potential to minimize the disease burden. Further studies will determine the relevance of experimental studies with zinc on human viral diseases. "

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923946/

Dated March 2021

thanks lee, i posted similar stuff recently.

lets say zinc reduces your risk of hospitalisation or dying by a mere 10 %

thats a saving of billions for the health sector and maybe 100,000 lives world wide.

why would you not do that.

we know losing 10 KG reduces your risk of hospitalisation and death by nearly 50 %.

people have had 18 months to lose that.

its less then 1 kg a month.

it would saves billions and probably millions of lives worldwide.

think that our pharmaceutical companies and politicians will promote that idea.

not a chance

it has never been mentioned

even once.

instead they close gyms and lock people up

they close healthy resturants and encourage people to buy maccas and dominoes.

its a disgrace

::) ::) ::)

Get your snake oil here!!!

Qualified salesmen handing out the most up to date medical advice & cure alls.

See Lee, Yadda & Scoot to get your daily dose of

horseshit, horse wormer in a tasty zinc paste.

Don't bend over or you'll get a double dose.

are you fat gnads?

if you are and you havent lost 10 kg in the last 18 months,
why not ?

its not snake oil.

the unthinking masses simply dont like the message.

yes rollup your sleeves and get the vax,
thats the easy part
that doesnt make you healthy.

covid is still going to attack the unhealthy.

when did we think gladys and dan and scomo became experts on health .
when did we think doctors became experts on health

they are experts on disease
australia has "civilisational diabetes"

covid has exposed just how unhealthy many people are and how little they are willing to do about it.

lift some kettlebells and hit the greens  :D :D :D :D

Gnads wrote on Sep 14^th, 2021 at 7:27pm:

See Lee, Yadda & Scoot to get your daily dose of

Obviously you didn't understand the web address.


lee wrote on Sep 14^th, 2021 at 6:23pm:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923946/

aquascoot wrote on Sep 14^th, 2021 at 4:06pm:

lee wrote on Sep 14th, 2021 at 4:00pm: "Conclusion Currently, indirect evidence suggests zinc may potentially reduce the risk, duration and severity of SARS-CoV-2 infections, particularly for populations at risk of zinc deficiency including people with chronic disease co-morbidities and older adults. Direct evidence to determine if zinc is effective for either prevention or treatment of SARS-CoV-2 is pending. In the interim, assessing zinc status of people with chronic diseases and older adults, as part of a SARS-CoV-2 clinical work-up, is reasonable as both groups have a higher risk of zinc deficiency/insufficiency and poorer outcomes from SARS-CoV-2." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395818/ pending ;D ;D ;D ;D do you think big government or big pharma are going to study this  :D :D :D. 17/ Politics, the media, science, and the healthcare industries are all corrupt, to varying degrees. Scientists and doctors can be bought as easily as politicians.

Pfizer made $35 billion so far from this vaccine not including future booster shots makes that $2.3 billion fine they got in 2009 look like chickenfeed.

As for Zinc just eat some Sydney Rock Oysters every week.

;)

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